Resveratrol supplementation reduces ACE2 expression in human adipose tissue

Angiotensin converting enzyme-2 (ACE2) is the cell-surface receptor enabling cellular entry of SARS-CoV-2. ACE2 highly expressed in adipose tissue (AT), rendering AT a potential SARS-CoV-2 reservoir contributing to massive viral spread COVID-19 patients with obesity. Although rodent and cell studies suggest that polyphenol resveratrol alters ACE2, human are lacking. Here, we investigated effects 30-days supplementation on RAS components skeletal muscle men obesity placebo-controlled cross-over study. Resveratrol markedly decreased (~40%) leptin (~30%), but did neither alter angiotensinogen, ACE AT1R expression nor components. These findings demonstrate reduces AT, which might dampen COVID-19.